Alaptide Could Have Hasten Clinical Recovery Among Dogs with Atopic Dermatitis

Abstract

Atopic dermatitis is a chronic inflammatory skin disease  in dogs, characterized by intense pruritus and increased IgE  production. The aim of this study was to evaluate the effects of a topical cream containing alaptide on skin pH and hydration levels, which are important indicators of skin health, in dogs with atopic dermatitis. A total of 24 dogs were included in the study, and the inclusion criteria were determined based on the Favrot criteria, clinical scoring, and allergic evaluations. Epidermal pH and hydration measurements were analyzed in lesional and non- lesional skin areas using a non-invasive device designed to assess skin health. Analyses were performed before treatment and at the end of the second week following the initiation of treatment with 1% alaptide. The obtained data were analyzed using the Wilcoxon test. After treatment, a statistically significant increase was detected in epidermal pH values (from 5.91±1.34 to 7.16±0.42; p=0.02), along with a marked increase in skin hydration levels (from 31.7±8.35 to 56.7±9.35; p=0.01). Evaluation of the findings indicated that alaptide significantly improved epidermal biophysical parameters and contributed to the regeneration of the skin barrier. In conclusion, topical application containing 1% alaptide may be considered a regenerative and supportive therapeutic option in the treatment of atopic dermatitis in dogs.