Zonulin Levels in Calves with Respiratory Distress Syndrome: Is There Field Evidence of Proof for Gut-Lung Axis in Calves?

Abstract

 Zonulin, a highly recognized protein, influence the integrity of intercellular connections among intestinal route. Respiratory disease syndrome (rDs), has been denoted as insufficient oxygen demands along with elevated retention of carbon dioxide among neonatal calves causing respiratory acidosis. The latter syndrome has been more frequently detected among premature calves, dedicated/linked to surfactant deficiency. The present article, namely field study discussed ‘gut-lung axis’ in calves with rDs, along with searching for the evidence of leaky gut and intestinal permability alterations. Therefore, the objective of this present field study was to make interpretation for gut-lung axis in calves with rDs. In field conditions to those 5 different milk-fed veal facilities donated farms, 78 calves were were classified as healthy (n=19) or with rDs (n=59). Commercially available specific Bovine Zonulin ELISA test kits were used. The mean zonulin levels (ng/mL) in calves with rDs presenting score 2 and score 3 were detected as 66,71± 4,602 respectively denoting statistically significant alterations in contrast to healthy calves 21.69±4.234 (p<0.05). Conclusion: It should not be unwise to draw preliminary message that gut-lung axis existed in calves with rDs to those of which treatment practices should be directed to intestinal environment.