Shear Wave Elastography as a Diagnostic Tool for Feline Hepatic Lipidosis: A Case Report
DOI:
https://doi.org/10.5281/zenodo.18147228Keywords:
Tissue elasticity, liver steatosis, shear wave elastography, cat, computed tomographyAbstract
Hepatik lipidoz (HL), ayda sık görülen bir hastalık hastalığıdır. Histopatoloji açısından altın standart olmaya devam etsin de, invaziv olmayan tanı araçlara olan ihtiyaç giderek artmaktadır. Bu vaka raporlarında, hepatik parankimal programlama Shear Wave Elastografisi (SWE) ve Bilgisayarlı Tomografi (BT) kullanılarak değerlendirildiği, HL tanısı konmuş yaşlı bir kedi sunulmaktadır. SWE ölçümleri, sol lobda 30,42 kPa ve sağ lobda 19,68 kPa kalp hızı ayrıntıları ortaya çıkıyor; bu değerler, sağlıklı bağlantılar için referans aralıklarından önemli ölçüde daha yüksektir. BT görüntülemesi, zekada azalmış zayıflama ve lipid infiltrasyonuyla uyumlu hipodens alanları gösteriliyor. Kontrast öncesi fazda, kalp ve dalak zayıflama değerleri sırasıyla 44,37 HU ve 55,84 HU olup, bu da kalp-dalak (L/S) başlangıçta 0,79 olma nedeni olmuştur; bu değer, insan literatüründe steatoz ile saklandığı gibi kayıtlı eşik mevcuttur. Kontrastlı portal venöz fazda da benzer bir L/S oranı olan 0,82 gözlemlendi. Histopatolojik inceleme, SWE ve BT ile uyumlu olarak Grade 3 hepatik lipidozu doğruladı. Bu, HL'li bir kedide SWE'nin tanıtım faydasını gösteren ilk vaka raporudur ve klinik olarak birleştirme invaziv olmayan ve nicel bir araç olarak potansiyelini ortaya koymaktadır.
References
Abdellah, O. M., Ali, M. E., Elsayed, A. H., Reem, R. T., & Abdel-Saeed, H. (2024). Clinical and diagnostic studies on feline hepatic lipidosis and the significance of miRNA-122 as a biomarker. Bulgarian Journal of Veterinary Medicine. Advance online publication. https://doi.org/10.15547/bjvm.2024-0078
Appleby, R. B., Vaden, S. L., Monteith, G., & Seiler, G. S. (2023). Shear wave elastography evaluation of cats with chronic kidney disease. Veterinary Radiology & Ultrasound, 64(2), 330–336.
Barsanti, J., Jones, B. D., Spano, J., et al. (1977). Prolonged anorexia associated with hepatic lipidosis in 3 cats. Feline Practice, May, 52–57.
Berzigotti, A., Tsochatzis, E., Boursier, J., et al. (2021). EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update. Journal of Hepatology, 75(3), 659–689. https://doi.org/10.1016/j.jhep.2021.05.025
Cassinotto, C., Boursier, J., Paisant, A., Guiu, B., Irles-Depe, M., Canivet, C., et al. (2021). Transient versus two-dimensional shear-wave elastography in a multistep strategy to detect advanced fibrosis in NAFLD. Hepatology, 73(6), 2196–2205.
Castera, L., Friedrich-Rust, M., & Loomba, R. (2019). Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease. Gastroenterology, 156(5), 1264–1281. https://doi.org/10.1053/j.gastro.2018.12.036
Castera, L. (2020). Non-invasive tests for liver fibrosis in NAFLD: Creating pathways between primary healthcare and liver clinics. Liver International, 40, 77–81. https://doi.org/10.1111/liv.14347
Ercolin, A. C. M., Uchôa, A. S., Aires, L. P. N., Gomes, D. R., Tinto, S. T., Feliciano, G. S. M., & Feliciano, M. A. R. (2024). Use of new ultrasonography methods for detecting neoplasms in dogs and cats: A review. Animals, 14(2), 312. https://doi.org/10.3390/ani14020312
Febo, E., Del Signore, F., Bernabò, N., Paolini, A., Simeoni, F., De Bonis, A., et al. (2023). Ultrasonography and sonoelastography characteristics of benign vs. malignant mesenteric lymph nodes in cats: An update. Animals, 13(16), 2664. https://doi.org/10.3390/ani13162664
Feeney, D. A., Anderson, K. L., Ziegler, L. E., Jessen, C. R., Daubs, B. M., & Hardy, R. M. (2008). Statistical relevance of ultrasonographic criteria in the assessment of diffuse liver disease in dogs and cats. American Journal of Veterinary Research, 69(2), 212–221.
Feliciano, M. A. R., Maronezi, M. C., Brito, M. B. S., Simões, A. P. R., Maciel, G. S., Castanheira, T. L. L., et al. (2015). Doppler and elastography as complementary diagnostic methods for mammary neoplasms in female cats. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 67, 935–939. https://doi.org/10.1590/1678-4162-8114
Heo, S. H., Yoon, Y. M., Hwang, T. S., Jung, D. I., & Lee, H. C. (2018). Imaging diagnosis of hepatic lipidosis in a cat. Korean Journal of Veterinary Research, 58(2).
Kim, K., Lee, J., So, J., Jang, Y. S., Jung, M., Kang, K., et al. (2020). Feasibility and reliability of two-dimensional shear-wave elastography of the liver of clinically healthy cats. Frontiers in Veterinary Science, 7, 614750. https://doi.org/10.3389/fvets.2020.614750
Kuwashiro, T., Takahashi, H., Hyogo, H., et al. (2020). Discordant pathological diagnosis of non-alcoholic fatty liver disease: A prospective multicenter study. JGH Open, 4(3), 497–502. https://doi.org/10.1002/jgh3.12289
Kuzi, S., Segev, G., Kedar, S., Yas, E., & Aroch, I. (2017). Prognostic markers in feline hepatic lipidosis: A retrospective study of 71 cats. Veterinary Record, 181(19), 512.
Park, S., Choi, J., Kim, K., Oh, D., Yoon, J., & Choi, M. (2021). Point shear wave elastography of the liver in healthy adult cats. American Journal of Veterinary Research, 82(4), 286–291.
Pavlick, M., Webster, C. R., & Penninck, D. G. (2019). Bleeding risk and complications associated with percutaneous ultrasound-guided liver biopsy in cats. Journal of Feline Medicine and Surgery, 21(6), 529–536.
Proot, S. J. M., & Rothuizen, J. (2006). High complication rate of an automatic Tru-Cut biopsy gun device for liver biopsy in cats. Journal of Veterinary Internal Medicine, 20(6), 1327–1333.
Puccinelli, C., Pelligra, T., Lippi, I., & Citi, S. (2023). Diagnostic utility of two dimensional shear wave elastography in nephropathic dogs and its correlation with renal contrast-enhanced ultrasound in course of acute kidney injury. Journal of Veterinary Medical Science, 85(11), 1216–1225.
Redhu, N., Rastogi, D., Yadav, A., Hariprasad, S., Jigar, Z., Tripathi, S., et al. (2015). Ultrasound elastography: Review. Current Medicine Research and Practice, 5(2), 67–71.
Rogier, J., Roullet, S., Cornélis, F., Biais, M., Quinart, A., Revel, P., et al. (2015). Noninvasive assessment of macrovesicular liver steatosis in cadaveric donors based on computed tomography liver-to-spleen attenuation ratio. Liver Transplantation, 21(5), 690–695.
Seo, J. W., Kim, Y. R., Jang, J. K., Kim, S. Y., Cho, Y. Y., Lee, E. S., & Lee, D. H. (2023). Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD. Ultrasonography, 42(3), 421–432.
Sigrist, R. M., Liau, J., El Kaffas, A., Chammas, M. C., & Willmann, J. K. (2017).
Ultrasound elastography: Review of techniques and clinical applications. Theranostics, 7(5), 1303–1330.
Tamura, M., Ohta, H., Shimbo, G., Osuga, T., Sasaki, N., Morishita, K., et al. (2019). Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease. Journal of Veterinary Internal Medicine, 33(5), 2067–2074.
Thampanitchawong, P., & Piratvisuth, T. (1999). Liver biopsy: Complications and risk factors. World Journal of Gastroenterology, 5(4), 301–304. https://doi.org/10.3748/wjg.v5.i4.301
Thanaboonnipat, C., Sutayatram, S., Buranakarl, C., & Choisunirachon, N. (2019). Renal shear wave elastography and urinary procollagen type III amino-terminal propeptide (uPIIINP) in feline chronic kidney disease. BMC Veterinary Research, 15, 1–10.
Watson, P. J. (2022). Hepatobiliary diseases in cats. In R. W. Nelson & G. J. Couto (Eds.), Small animal internal medicine (6th ed., pp. 561–567). Elsevier.
Webb, C. B. (2018). Hepatic lipidosis: Clinical review drawn from collective effort. Journal of Feline Medicine and Surgery, 20(3), 217–227. https://doi.org/10.1177/1098612X18758591
White, J., Gay, J., Farnsworth, R., Mickas, M., Kim, K., & Mattoon, J. (2014). Ultrasound elastography of the liver, spleen, and kidneys in clinically normal cats.
Veterinary Radiology & Ultrasound, 55(4), 428–434.
Zaleska-Dorobisz, U., Kaczorowski, K., Pawluś, A., Puchalska, A., & Inglot, M. (2013). Ultrasound elastography: Review of techniques and its clinical applications.
Brain, 6, 10–14.
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