Assessment of Whole Blood Parameters in Healthy Cats Under Enviromental Cigarette Smoke Exposure
Enviromental Cigarette Smoke Exposure on Healthy Cats
DOI:
https://doi.org/10.5281/zenodo.23413635Keywords:
Enviromental cigarette smoke, cat, whole blood, passive smoking, HaematologiaAbstract
The study aimed to evaluate whole blood parameters in healthy cats exposed to environmental tobacco smoke (ETS). Because humans and pets share living spaces, the potential effects of tobacco smoke on pets are becoming increasingly important. The study compared healthy domestic cats exposed to ETS (ETS group) with those not exposed (control group). It is known that tobacco smoke has toxic, mutagenic, and carcinogenic effects on living organisms through various exposure routes classified as first-, second-, and third-hand smoke. According to the study’s findings, the mean mean corpuscular hemoglobin (MCH) level in the SDE group was found to be statistically significantly higher than that in the control group (p=0.017). Additionally, the red blood cell distribution width (RDW) value was found to be statistically significantly lower in the SDE group compared to the control group (p=0.039). No statistically significant differences were observed between the groups regarding other complete blood count parameters (RBC, HGB, HCT, MCV, MCHC, WBC, LEN, MON, GRAN, PLT, PDW, PCT). In conclusion, this study demonstrated that environmental cigarette smoke exposure in healthy cats can lead to limited but statistically significant changes in complete blood count parameters. In particular, the differences in MCH and RDW values highlight the need for further research to investigate cats’ hematological responses to environmental cigarette smoke. These findings highlight the potential risks of environmental tobacco smoke exposure to pet health and underscore the need for more sensitive biomarkers and long-term follow-up studies.
References
Aytemur, Z., Akçay, Ş., & Elbek, O. (2010). Tütün ve Tütün Kontrolü (M. Karadağ & H. Bilgiç, Eds.; Vol. 10). AVES Yayıncılık.
Baker, R. R., Massey, E. D., & Smith, G. (2004). An overview of the effects of tobacco ingredients on smoke chemistry and toxicity. Food and Chemical Toxicology, 42(SUPPL.), 53–83. https://doi.org/10.1016/j.fct.2004.01.001
Bridges, A. B., Chb, M. B., Hill, M. A., Phd, M., Belch, J. J. F., & Md, F. (1993). Cigarette smoking increases white blood cell aggregation in whole blood. Journal of the Royal Society of Medicine, 86, 139–140.
Ferrante, G., Simoni, M., Cibella, F., Ferrara, F., Liotta, G., Malizia, V., Corsello, G., Viegi, G., & Grutta, S. La. (2013). Third-hand smoke exposure and health hazards in children. In Monaldi Arch Chest Dis (Vol. 79, Issue 1).mc
Flouris, A. D. (2009). Health and Human Services, Centers of Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. Inflammation & Allergy-Drug Targets, 8(5), 364–372.
Flouris, A. D., Poulianiti, K. P., Chorti, M. S., Jamurtas, A. Z., Kouretas, D., Owolabi, E. O., Tzatzarakis, M. N., Tsatsakis, A. M., & Koutedakis, Y. (2012). Acute effects of electronic and tobacco cigarette smoking on complete blood count. Food and Chemical Toxicology, 50(10), 3600–3603. https://doi.org/10.1016/j.fct.2012.07.025
Hutchinson, N. (2017). Evaluating the impact of environmental tobacco smoke on biological age markers: a canine model. University of Glascow.
Lindsay, R., Tsoh, J., Sung, H., & Max, W. (2016). Secondhand smoke exposure and serum cotinine levels among current smokers in the USA. Tobacco Control, 25(2), 224–231. https://doi.org/10.1136/tobaccocontrol-2014-051782
Matt, G. E., Quintana, P. J. E., Destaillats, H., Gundel, L. A., Sleiman, M., Singer, B. C., Jacob, P., Benowitz, N., Winickoff, J. P., Rehan, V., Talbot, P., Schick, S., Samet, J., Wang, Y., Hang, B., Martins-Green, M., Pankow, J. F., & Hovell, M. F. (2011). Thirdhand tobacco smoke: Emerging evidence and arguments for a multidisciplinary research agenda. In Environmental Health Perspectives (Vol. 119, Issue 9, pp. 1218–1226). https://doi.org/10.1289/ehp.1103500
Max, W., Sung, H. Y., & Shi, Y. (2012). Deaths from secondhand smoke exposure in the United States: Economic implications. American Journal of Public Health, 102(11), 2173–2180. https://doi.org/10.2105/AJPH.2012.300805
Onor, I. C. O., Stirling, D. L., Williams, S. R., Bediako, D., Borghol, A., Harris, M. B., Darensburg, T. B., Clay, S. D., Okpechi, S. C., & Sarpong, D. F. (2017). Clinical effects of cigarette smoking: Epidemiologic impact and review of pharmacotherapy options. In International Journal of Environmental Research and Public Health (Vol. 14, Issue 10). MDPI. https://doi.org/10.3390/ijerph14101147
Panagiotakos, D., Pitsavos, C., Chrysohoou, C., Skoumas, J., Masoura, C., Toutouzas, P., & Stefanadis, C. (2004). Effect of exposure to secondhand smoke on markers of inflammation: the ATTICA study. The American Journal of Medicine, 116(3), 145–150. https://doi.org/10.1016/j.amjmed.2003.07.019
Ronchetti, R., Macri, F., Ciofetta, G., Indinnimeo, L., Cutrera, R., Bonci, E., Antognoni, G., & Martinez, F. (1990). Increased serum IgE and increased prevalence of eosinophilia in 9-year-old children of smoking parents. Journal of Allergy and Clinical Immunology, 86(3), 400–407. https://www.sciencedirect.com/science/article/pii/S0091674905801046
Sarma, P. R. (1990). Red cell indices. In H. K. Walker, W. D. Hall, & J. W. Hurst (Eds.), Clinical methods: The history, physical, and laboratory examinations (3rd ed.). Butterworths. https://www.ncbi.nlm.nih.gov/books/NBK260/
Taioli, E. (2008). Gene-environment interaction in tobacco-related cancers. In Carcinogenesis (Vol. 29, Issue 8, pp. 1467–1474). https://doi.org/10.1093/carcin/bgn062
Tan, X., Vrana, K., & Ding, Z. M. (2021). Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions. In Frontiers in Behavioral Neuroscience (Vol. 15). Frontiers Media S.A. https://doi.org/10.3389/fnbeh.2021.758252
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