EVALUATION OF RENAL FUNCTIONS IN CATS WITH CARDIOMYOMYOPATHY

Abstract

This study was carried out to evaluate the effects of heart failure due to cardiomyopathy on renal function in cats. For this purpose,physical examination, haematological and biochemical analyses, radiographic, electrocardiographic and echocardiographic imaging and cases were systematically investigated. The study material consisted of 25 cats in two different groups, the study group consisting of cats with cardiomyopathy (n:15) and the control group consisting of healthy cats (n:10).N-terminal pro B-type natriuretic peptide (NT-proBNP) levels were significantly increased in cats with cardiomyopathy (P<0.05) and this increase was significantly correlated with left atrial diameter (LA), ventricular wall thickness (LVPF) and pulmonary artery flow velocity (PAVmax) determined echocardiographically (ECHO). In the renal parameters, especially SDMA was found toreflect the early renal effects than creatinine and BUN, which are classical renal markers, and an increase in SDMA values wasfound (P<0.05). In addition, SDMA showed significant correlations with some erythrogram and thrombogram parameters,suggesting its effects on haematopoiesis. In conclusion, in this study, it was observed that cardiomyopathy-induced renal functions were affected early and significantly in cats. The use of biomarkers such as NT-proBNP and SDMA integrated into classical methods is important for early diagnosis anddevelopment of appropriate treatment strategies.