Prognostic Value of Serum C-Reactive Protein (CRP), Procalcitonin, Fibrinogen, and D-Dimer Levels in Dogs with Parvoviral Gastroenteritis

Abstract

This study investigated the prognostic value of various biomarkers in 20 puppies with parvoviral gastroenteritis. After treatment, 13 dogs recovered, and 7 died during the treatment process.

Clinically, general condition disorders such as loss of consciousness and fainting have been associated with increased mortality. Hematologically, marked leukopenia and lymphopenia were observed in deceased dogs, indicating the suppressive effect of parvovirus on the immune system.

Among the biomarkers examined, fibrinogen and D-dimer levels were the most reliable indicators with high accuracy (AUC = 1.00) in mortality prediction. CRP and procalcitonin levels did not differ significantly between the surviving and deceased groups.

A significant decrease in treated and recovered dogs, especially in D-dimer and APTT levels, was detected, indicating an improvement in the coagulation system.

Fibrinogen and D-dimer are reliable biomarkers to predict disease severity and mortality risk in dogs with parvoviral enteritis. In contrast, CRP and procalcitonin are not suitable for this purpose. Early monitoring of coagulation parameters can improve clinical management.