Relationships between symmetric dimethylarginine (SDMA), blood urea nitrogen and creatinine levels in dogs

SDMA, Creatinine and BUN levels in dogs

Abstract

Renal failure is a frequently encountered disorder of the dogs and cats. Blood urea and creatinine levels are the conventional diagnostic parameters, but elevate only after  advanced stage, so a significant period for the therapy onset is mislayed. Serum symetric dimethly arginine (SDMA) is a spesific and early biomarker of renal insufficiency. The aim of this study is to investigate the state of relationships between SDMA, BUN and creatinine levels in dogs. In the present study, SDMA, BUN and creatinine levels are determined in 50 dogs bu ELISA. Obtained results displayed an absence of a correlation, but also indicated renal insufficiency in 14% of the dogs which had none related clinical suffering or laboratory finding. This striking ratio displayes the diagnostic efficiency of SDMA and also emphasizes the requirement of routine SDMA usage in clinical practice on behalf of early diagnosis, theurapeutic success, therapy expanses and animal welfare.